Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria
Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component.As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria.The safe-for-human-use hydroxyquinoline analog ionophore PBT2 has been previously shown to break polymyxin re